Advancing better science - for both people & animals.

The 3Rs Collaborative (3RsC) is a nonprofit guiding the research community toward ethical animal research. By uniting science-driven expertise with a commitment to welfare, 3RsC makes it achievable for every lab, institution, and professional to implement the 3Rs: Refinement, Reduction, and Replacement. Our mission: advance better science for people and animals, together.

What are the 3Rs?.

Refinement refers to methods that minimize the pain, suffering, and distress of research animals as well as improves their welfare.


Reduction refers to methods that minimize the number of animals required per experiment, or study design, to achieve robust results.


Replacement refers to methods or technologies which avoid, or replace, the use of animals.

Collaborative Initiatives Making an Impact

See the 3Rs in action through our flagship initiatives:

Discover how these programs are driving real change for science and welfare.

Join Our Mission

Ready to Make a Difference?

3RsC is a registered 501(c)(3) nonprofit—your membership or donation directly fuels new resources, outreach, and impact. See how our community has replaced over 9,000 animals in research just last year. Every action counts. Become part of the movement to advance humane research. Whether you want to access expert resources, connect with peers, or lead the change in your institution—3RsC welcomes your participation.

Photo Credit: Kathy West/California Primate Research Center