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We collaborate to increase industry adoption & regulatory acceptance of translational digital biomarkers that refine and reduce animals in research.
Translational digital biomarkers are objective, quantifiable physiological and behavioral data that are collected and measured by means of digital technologies. They are clinically relevant and translational between preclinical studies and the clinic. These biomarkers have the potential to help reduce the number of laboratory animals needed for biomedical research and refine their lives during necessary projects.
The 3RsC Translational Digital Biomarkers Initiative was established as a collaboration among end-users and technology providers to establish an improved understanding of the value and to facilitate the optimal implementation of digital biomarker technologies in research. The initiative engages end-users and those interested in learning more about how these technologies can be used to promote the 3Rs.
Our initiative first published a review manuscript titled Emerging Role of Translational Digital Biomarkers Within Home Cage Monitoring Technologies in Preclinical Drug Discovery & Development that provides an overview of digital monitoring technologies for use in preclinical studies.
Our initiative’s most recent publication, Validation Framework for Digital In Vivo Measures, outlines the V3 framework, a validation framework that encompasses verification, analytical validation, and clinical validation, and adapts this to ensure the reliability and relevance of digital measures for a preclinical context.
